![]() ![]() This is a retrospective study of patients admitted to the hospital for acute acetaminophen overdose over a period of 5 years (1 January 2004 to 31 December 2008). The objective of this study was to investigate the relation between the incidence of different types of ADR and serum acetaminophen concentration in patients presenting to the hospital with acetaminophen overdose. However, during the infusion of the loading dose, different types of adverse drug reactions (ADR) may occur. CONCLUSION: ADR to IV-NAC were common among patients with acetaminophen overdose, but mostly minor and all reported adverse reactions were easily managed.Ībstract: Intravenous N-acetylcysteine is usually regarded as a safe antidote. Comparative results of the characteristics of patients who reacted to IV-NAC and nonreactors showed that patients with ADR had no significant difference in age, gender, ethnicity, amount ingested, latency time, and acetaminophen level than nonreactors. There were no ADR in 42 (33.6%) patients. The following ADR were significantly associated with IV-NAC administration: vomiting (p =. Of those patients, 83 (69.7%) had been treated with IV-NAC versus 36 (30.3%) who had not (p <. Different types of ADR were observed in 119 (46.7%) cases. RESULTS: Two hundred and fifty five patients were studied. Pearson chi-square test or Fisher's exact test, student's t test, and Mann-Whitney U test were used in univariate analysis. The primary outcome of interest in this study was the occurrence of ADR during NAC administration. METHODS: This is a retrospective study of patients admitted to the hospital for acute acetaminophen overdose over a period of 4 years (1 January 2005 to 31 December 2008). ![]() ![]() OBJECTIVE: The aim of this study was to investigate the type and incidence of ADR induced by IV-NAC in patients treated for acetaminophen overdose. However, its use is not without adverse drug reactions (ADR) that might affect therapeutic outcome or lead to treatment delay. BACKGROUND: Intravenous N-acetylcysteine (IV-NAC) is widely recognized as the antidote of choice for acetaminophen overdose. ![]()
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